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Prozac No Better Than Placebo

Posted by Amy S.F. Lutz

It's one thing to read about a study disproving the therapeutic benefits of St. John's Wort, or claiming that OTC cough syrup doesn't get the job done as well as three ounces of dark chocolate.  But SSRIs are in another class altogether.  Antidepressants are the most commonly prescribed drugs in the United States.  Over 118 million prescriptions were written in 2005.

Now, a British study done at the University of Hull claims that SSRIs just don't work for most patients.  Professor Irving Kirsch combined the results of 35 clinical trials involving 5000 subjects, and found that only those suffering from the most severe cases of depression got any greater benefit from an antidepressant than they did from a sugar pill.

And Professor Kirsch isn't the first expert to question whether antidepressants are being overprescribed.  Dr. Ronald Dworkin reached the same  conclusion without the benefit of Kirsch's data.  In his book, "Artificial Unhappiness: The Dark Side of the New Happy Class," Dr. Dworkin claims, "Doctors are now medicating unhappiness . . . Too many people take drugs when they really need to be making changes in their lives."

It's not like SSRIs are benign happy pills.  There are plenty of side effects, including anxiety, insomnia, nausea, headaches, vomiting and suicide. 

So:  is this just another gigantic conspiracy on the part of the big pharmaceutical companies?  (Because you know how much I hate Big Pharm and love to blame everything on them).  

Actually . . . yes, in part.   A 2005 study in the Journal of the American Medical Association found that many doctors will pretty much prescribe SSRIs to any patient who asks for it.  And most of those patients ask for antidepressants after seeing ads on TV or in magazines featuring shiny happy medicated people frolicking in fields.

I'm depressed just reading about this enormous scam.  Think I'll go for a run - because exercise is one thing that has been proven to relieve the symptoms of depression.  It's free, and all the side-effects are positive.  So . . . see you on the track!


Comments

 

cooper1178 said:

I really wonder what specific drugs they were using, and what specific kinds of depression they were treating.  There is a huge difference between the horse's share Prozac cocktail my mother takes to treat her bi-polar disease and someone taking a low dose of Zoloft because they're "in a funk."  My siblings and I all experienced depression-like symptoms during growth spurts in high school and because of our mom's background, they'd put us Zoloft.  I have always thought this was more for the placebo effect, and the doctor's wanting to get my mom off his back, than for actual treatment.  But I've also seen my mom off meds, and her drugs are most definitely doing something.

I guess that's pretty much what they're saying, but I'd like to see the specifics - what classifies as "severe."

February 26, 2008 3:38 PM
 

Brett Singer said:

@cooper1178: I read a bit of the study (was going to post but asflutz beat me to it). "Severe" means hitting a certain level on a particular psychiatric scale (I'm not sure that I'm using the correct phrasing here). I believe that they had a basis for the statement of "severity"; that is, it was more of a term of art rather than a colloquialism. The study looks like it was fairly thorough, although I completely agree that if people take from it a message of "anti-depressants don't do anything," that's pretty dangerous.

February 26, 2008 7:19 PM
 

Cassie said:

Bi-polar, schizophrenic, clinically depressed. Yes they all need medication.  But I have friends on pills for YEARS because they had the blues after they gained weight,had a baby or they just feel overwhelmed by life.  These are parents now.  I once made the mistake of saying I was glad China was limiting adotpion to those who had been off anti-depressants therapies.  Being no longer depressed = better able to handle stress of adopting a traumatised toddler.  The ladies in my rathr large playgroup got really quiet when I said that. So I go, "Wait, How many of you are on meds now?"  All but one raised their hands!  That is 8 out of 10 of us!  One had a baby recently and she said she had worried about taking them while pregnant but the baby "seemed fine".  She did not want to risk feeling down while pregnant.  She had been on meds for over a decade for generalized anxiety aka poor coping skills.  Thank goodness she took her own happiness mroe seriously than the health of her child.  Oh and no, none of them see a therapist for any sort of behavior modification at all.  They are too busy. Just give me a happy pill!  

February 26, 2008 8:50 PM

About Amy S.F. Lutz

Amy S.F. Lutz's work has appeared in dozens of literary journals, including Cream City Review, The American Poetry Review, Puerto del Sol, and Mid-American Review. She and her husband have five children. Amy and her sister chronicle their adventures in communal living in their blog whoelsewantstoliveinmyhouse.com

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